C4orf49 antibody (AA 1-155)

Catalog No. ABIN7980113

The Rabbit Polyclonal anti-C4orf49 antibody (ABIN7980113) specifically detects C4orf49 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for C4orf49 antibody (AA 1-155) (ABIN7980113)

Target: C4orf49 (Chromosome 4 Open Reading Frame 49 (C4orf49))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C4orf49 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Grade: Carrier-free

Product Details anti-C4orf49 Antibody

Binding Specificity: AA 1-155

Purpose: Anti-MGARP Antibody

Predicted Reactivity: Human C4orf49,MGARP shares 67.3% amino acid (aa) sequence identity with mouse C4orf49,MGARP.

Characteristics: Anti-MGARP Antibody. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human C4orf49/MGARP recombinant protein (Position: M1-E155). Human C4orf49/MGARP shares 67.3% amino acid (aa) sequence identity with mouse C4orf49/MGARP.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for C4orf49

Target: C4orf49 (Chromosome 4 Open Reading Frame 49 (C4orf49))

Alternative Name: MGARP

Background:

Background: MGARP is highly enriched in steroidogenic tissues and the visual system. Interestingly, its expression increases as mice develop. Early in development, MGARP is mainly detected in the retina and adrenal gland. At this early developmental stage, its expression is not detectable in the gonads, but its expression in the gonads dramatically increases during the first 2-4 wk after birth. Importantly, MGARP levels correlate with estrogen levels in the ovaries during the estrous cycle, and estrogen regulates the expression of MGARP in a tissue-specific manner and through a feedback regulatory mechanism. Functional inhibition of GnRH with an antagonist strongly reduces MGARP levels, and knockout of leptin (ob/ob) significantly reduces the MGARP expression in follicular granular cells. We proposed a model that elucidates the role MGARP plays in the HPG axis. Within the HPG axis loop, MGARP participates in hormone biosynthesis while being under the regulation of the hormones derived from the HPG axis.

Gene Full Name: mitochondria localized glutamic acid rich protein

Molecular Weight: 38 kDa

Gene ID: 84709

UniProt: Q8TDB4