C6orf150 antibody (AA 208-522) (Cy3)

Catalog No. ABIN7980126

This Rabbit Polyclonal antibody specifically detects C6orf150 in FACS. It exhibits reactivity toward Human.

Quick Overview for C6orf150 antibody (AA 208-522) (Cy3) (ABIN7980126)

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C6orf150 antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-C6orf150 Antibody (Cy3)

Binding Specificity: AA 208-522

Purpose: Anti-CGAS Antibody Cy3 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CGAS recombinant protein (Position: L208-F522).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for C6orf150

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Alternative Name: CGAS

Background:

Background: cGAS (cyclic GMP-AMP synthase), also known as MB21D1 (Mab-21 domain containing 1), h-cGAS or C6orf150, is a 522 amino acid cytoplasmic nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. cGAS is suggested to have antiviral activity by acting as a key cytosolic DNA sensor. cGAS binds to cytosolic DNA, which leads to cGAMP synthesis and activation of TMEM173, thereby trigger type-I interferon production. Expressed in monocytic cell line THP1, cGAS exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 6q13.

Gene Full Name: cyclic GMP-AMP synthase

Gene ID: 115004

UniProt: Q8N884

Pathways: Activation of Innate immune Response