C6orf150 antibody (AA 208-522) (HRP)

Catalog No. ABIN7980131

The HRP-conjugated Rabbit Polyclonal anti-C6orf150 antibody (ABIN7980131) specifically detects C6orf150 in WB, IHC and ELISA. The antibody is reactive with Human samples.

Quick Overview for C6orf150 antibody (AA 208-522) (HRP) (ABIN7980131)

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C6orf150 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-C6orf150 Antibody (HRP)

Binding Specificity: AA 208-522

Purpose: Anti-CGAS Antibody HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CGAS recombinant protein (Position: L208-F522).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for C6orf150

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Alternative Name: CGAS

Background:

Background: cGAS (cyclic GMP-AMP synthase), also known as MB21D1 (Mab-21 domain containing 1), h-cGAS or C6orf150, is a 522 amino acid cytoplasmic nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. cGAS is suggested to have antiviral activity by acting as a key cytosolic DNA sensor. cGAS binds to cytosolic DNA, which leads to cGAMP synthesis and activation of TMEM173, thereby trigger type-I interferon production. Expressed in monocytic cell line THP1, cGAS exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 6q13.

Gene Full Name: cyclic GMP-AMP synthase

Gene ID: 115004

UniProt: Q8N884

Pathways: Activation of Innate immune Response