C6orf150 antibody (AA 352-504)

Catalog No. ABIN7980136

The Rabbit Polyclonal anti-C6orf150 antibody is suitable to detect C6orf150 in samples from Human and Mouse. It has been validated for WB, IHC, ELISA, ICC and IF.

Quick Overview for C6orf150 antibody (AA 352-504) (ABIN7980136)

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C6orf150 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-C6orf150 Antibody

Binding Specificity: AA 352-504

Purpose: Anti-cGAS Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-cGAS Antibody. Tested in WB, IHC, ICC/IF, ELISA. This antibody reacts with Human, Mouse.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human cGAS recombinant protein (Position: A352-F504).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for C6orf150

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Alternative Name: Cgas

Background:

Background: cGAS (cyclic GMP-AMP synthase) is a cytosolic DNA sensor that serves to mount an immune response against the invasion of microbial pathogens such as viruses. cGAS normally resides as an inactive protein in the cell. Upon binding to DNA, cGAS undergoes a conformational change to an active state and produces the second messenger cyclic GMP-AMP (cGAMP) from ATP and GTP, which is subsequently detected by the cyclic-dinucleotide sensor STING, an ~40 kDa dimeric transmembrane protein at the endoplasmic reticulum (ER). cGAS not only is found in the cytosol but has a multifaceted cellular distribution that involves localization at the cell membrane and in the nucleus (PMID: 32424334). The calculated molecular weight of cGAS is 58 kDa. With post-translational modification, the MW of cGAS will be migrated to 70 kDa.

Gene Full Name: cyclic GMP-AMP synthase

Molecular Weight: 58-65 kDa

Gene ID: 214763

UniProt: Q8C6L5

Pathways: Activation of Innate immune Response