C6orf150 antibody (AA 352-504) (APC)

Catalog No. ABIN7980144

This Rabbit Polyclonal antibody specifically detects C6orf150 in FACS. It exhibits reactivity toward Human and Mouse.

Quick Overview for C6orf150 antibody (AA 352-504) (APC) (ABIN7980144)

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C6orf150 antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Product Details anti-C6orf150 Antibody (APC)

Binding Specificity: AA 352-504

Purpose: Anti-cGAS Antibody APC Conjugated

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human cGAS recombinant protein (Position: A352-F504).

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for C6orf150

Target: C6orf150 (Chromosome 6 Open Reading Frame 150 (C6orf150))

Alternative Name: Cgas

Background:

Background: cGAS (cyclic GMP-AMP synthase) is a cytosolic DNA sensor that serves to mount an immune response against the invasion of microbial pathogens such as viruses. cGAS normally resides as an inactive protein in the cell. Upon binding to DNA, cGAS undergoes a conformational change to an active state and produces the second messenger cyclic GMP-AMP (cGAMP) from ATP and GTP, which is subsequently detected by the cyclic-dinucleotide sensor STING, an ~40 kDa dimeric transmembrane protein at the endoplasmic reticulum (ER). cGAS not only is found in the cytosol but has a multifaceted cellular distribution that involves localization at the cell membrane and in the nucleus (PMID: 32424334). The calculated molecular weight of cGAS is 58 kDa. With post-translational modification, the MW of cGAS will be migrated to 70 kDa.

Gene Full Name: cyclic GMP-AMP synthase

Gene ID: 214763

UniProt: Q8C6L5

Pathways: Activation of Innate immune Response