Claudin 11 antibody (C-Term) (Fluoro550)

Catalog No. ABIN7980382

The Rabbit Polyclonal anti-Claudin 11 antibody is suitable to detect Claudin 11 in samples from Human. It has been validated for FACS.

Quick Overview for Claudin 11 antibody (C-Term) (Fluoro550) (ABIN7980382)

Target: Claudin 11 (CLDN11)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 11 antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-Claudin 11 Antibody (Fluoro550)

Binding Specificity: C-Term

Purpose: Anti-CLDN11 Antibody Fluoro550 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CLDN11, which shares 85% amino acid (aa) sequence identity with both mouse and rat CLDN11.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Claudin 11

Target: Claudin 11 (CLDN11)

Alternative Name: CLDN11

Background:

Background: Claudin-11 is a protein that in humans is encoded by the CLDN11 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Full Name: claudin 11

Gene ID: 5010

UniProt: O75508

Pathways: Hepatitis C