Claudin 7 antibody (C-Term) (Fluoro488)

Catalog No. ABIN7980513

This Rabbit Polyclonal antibody specifically detects Claudin 7 in FACS. It exhibits reactivity toward Mouse.

Quick Overview for Claudin 7 antibody (C-Term) (Fluoro488) (ABIN7980513)

Target: Claudin 7 (CLDN7)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 7 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-Claudin 7 Antibody (Fluoro488)

Binding Specificity: C-Term

Purpose: Anti-Claudin 7/CLDN-7 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse Claudin 7/CLDN-7, which shares 87% and 100% amino acid (aa) sequence identity with human and rat Claudin 7/CLDN-7, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Claudin 7

Target: Claudin 7 (CLDN7)

Alternative Name: Cldn7

Background:

Background: Claudin-7 is a protein that in humans is encoded by the CLDN7 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed constitutively in the mammary epithelium throughout development, and might be involved in vesicle trafficking to the basolateral membrane. It is essential for NaCl homeostasis in distal nephrons. The knockout mice lacking this gene showed severe salt wasting, chronic dehydration, and growth retardation, and died within 12 days after birth. Alternatively spliced transcript variants have been found for this gene.

Gene Full Name: claudin 7

Gene ID: 53624

UniProt: Q9Z261

Pathways: Hepatitis C