Claudin 7 antibody (AA 92-211) (Cy3)

Catalog No. ABIN7980523

The Rabbit Polyclonal anti-Claudin 7 antibody is suitable to detect Claudin 7 in samples from Human. It has been validated for FACS.

Quick Overview for Claudin 7 antibody (AA 92-211) (Cy3) (ABIN7980523)

Target: Claudin 7 (CLDN7)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 7 antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-Claudin 7 Antibody (Cy3)

Binding Specificity: AA 92-211

Purpose: Anti-Claudin 7/CLDN-7 Antibody Cy3 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Claudin 7/CLDN-7 recombinant protein (Position: F92-V211).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Claudin 7

Target: Claudin 7 (CLDN7)

Alternative Name: CLDN7

Background:

Background: Claudin-7 is a protein that in humans is encoded by the CLDN7 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed constitutively in the mammary epithelium throughout development, and might be involved in vesicle trafficking to the basolateral membrane. It is essential for NaCl homeostasis in distal nephrons. The knockout mice lacking this gene showed severe salt wasting, chronic dehydration, and growth retardation, and died within 12 days after birth. Alternatively spliced transcript variants have been found for this gene.

Gene Full Name: claudin 7

Gene ID: 1366

UniProt: O95471

Pathways: Hepatitis C