CLPB antibody (AA 438-707) (Biotin)

Catalog No. ABIN7980566

The Biotin-conjugated Rabbit Polyclonal anti-CLPB antibody (ABIN7980566) specifically detects CLPB in WB, ELISA and IHC. The antibody is reactive with Human, Mouse, Rat and Monkey samples.

Quick Overview for CLPB antibody (AA 438-707) (Biotin) (ABIN7980566)

Target: CLPB (ClpB Caseinolytic Peptidase B Homolog (CLPB))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLPB antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-CLPB Antibody (Biotin)

Binding Specificity: AA 438-707

Purpose: Anti-CLPB Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human CLPB recombinant protein (Position: Q438-I707).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CLPB

Target: CLPB (ClpB Caseinolytic Peptidase B Homolog (CLPB))

Alternative Name: CLPB

Background:

Background: This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants.

Gene Full Name: ClpB family mitochondrial disaggregase

Gene ID: 81570

UniProt: Q9H078