Cofilin 2 antibody (C-Term) (Fluoro647)

Catalog No. ABIN7980883

The Rabbit Polyclonal anti-Cofilin 2 antibody is suitable to detect Cofilin 2 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for Cofilin 2 antibody (C-Term) (Fluoro647) (ABIN7980883)

Target: Cofilin 2 (CFL2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cofilin 2 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-Cofilin 2 Antibody (Fluoro647)

Binding Specificity: C-Term

Purpose: Anti-Cofilin 2/CFL2 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: identical to the related mouse sequence.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Cofilin 2, identical to the related mouse sequence.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Cofilin 2

Target: Cofilin 2 (CFL2)

Alternative Name: CFL2

Background:

Background: Cofilin 2 (muscle), also known as CFL2, is a protein which in humans is encoded by the CFL2 gene. It is mapped to 14q12. This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. And this protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH -dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.

Gene Full Name: cofilin 2

Gene ID: 1073

UniProt: Q9Y281

Pathways: Caspase Cascade in Apoptosis