C7 antibody (AA 233-453) (Fluoro488)

Catalog No. ABIN7981439

The Fluoro488-conjugated Rabbit Polyclonal anti-C7 antibody (ABIN7981439) specifically detects C7 in FACS. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for C7 antibody (AA 233-453) (Fluoro488) (ABIN7981439)

Target: C7 (Complement Component C7 (C7))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C7 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-C7 Antibody (Fluoro488)

Binding Specificity: AA 233-453

Purpose: Anti-Complement C7 Antibody Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human Complement C7 recombinant protein (Position: R233-D453).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for C7

Target: C7 (Complement Component C7 (C7))

Alternative Name: C7

Background:

Background: This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency.

Gene Full Name: complement C7

Gene ID: 730

UniProt: P10643

Pathways: Complement System