Complement Factor I antibody (AA 19-220) (HRP)

Catalog No. ABIN7981575

This Rabbit Polyclonal antibody specifically detects Complement Factor I in WB, IHC and ELISA. It exhibits reactivity toward Human and Rat.

Quick Overview for Complement Factor I antibody (AA 19-220) (HRP) (ABIN7981575)

Target: Complement Factor I (CFI)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complement Factor I antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-Complement Factor I Antibody (HRP)

Binding Specificity: AA 19-220

Purpose: Anti-Factor I/CFI Antibody HRP Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: coli-derived human Factor I recombinant protein (Position: K19-D220). Human Factor I shares 70.7%,71.2% amino acid (aa) sequence identity with mouse,rat Factor I,respectively.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human Factor I recombinant protein (Position: K19-D220). Human Factor I shares 70.7% and 71.2% amino acid (aa) sequence identity with mouse and rat Factor I, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Complement Factor I

Target: Complement Factor I (CFI)

Alternative Name: CFI

Background:

Background: Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene.

Gene Full Name: complement factor I

Gene ID: 3426

UniProt: P05156

Pathways: Complement System