CUEDC2 antibody (C-Term) (Fluoro647)

Catalog No. ABIN7981975

The Rabbit Polyclonal anti-CUEDC2 antibody is suitable to detect CUEDC2 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for CUEDC2 antibody (C-Term) (Fluoro647) (ABIN7981975)

Target: CUEDC2 (CUE Domain Containing 2 (CUEDC2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CUEDC2 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-CUEDC2 Antibody (Fluoro647)

Binding Specificity: C-Term

Purpose: Anti-CUEDC2 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: identical to the related mouse sequence,and different from the related rat sequence by one amino acid.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human CUEDC2, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for CUEDC2

Target: CUEDC2 (CUE Domain Containing 2 (CUEDC2))

Alternative Name: CUEDC2

Background:

Background: CUEDC2 (Cue Domain-Containing Protein 2) is involved in ubiquitin-and proteasome-mediated degradation of progesterone receptor (PR, or PGR) and estrogen receptor (ER)-alpha. Hartz (2011) mapped the CUEDC2 gene to chromosome 10q24.32 based on an alignment of the CUEDC2 sequence with the genomic sequence (GRCh37). Using coimmunoprecipitation analysis and protein pull-down assays, Zhang et al. (2007) confirmed that CUEDC2 interacted with the PRB isoform of PR. Mutation analysis revealed that the IF domain of PRB and the CUE domain of CUEDC2 were required for the interaction. CUEDC2 reduced PRB protein content and promoted progesterone-induced PRB degradation via the ubiquitin-proteasome pathway.

Gene Full Name: CUE domain containing 2

Sequence Similarities: Belongs to the CUEDC2 family.

Gene ID: 79004

UniProt: Q9H467