Cullin 4A antibody (AA 494-759) (Fluoro647)

Catalog No. ABIN7982041

The Rabbit Polyclonal anti-Cullin 4A antibody is suitable to detect Cullin 4A in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for Cullin 4A antibody (AA 494-759) (Fluoro647) (ABIN7982041)

Target: Cullin 4A (CUL4A)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cullin 4A antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-Cullin 4A Antibody (Fluoro647)

Binding Specificity: AA 494-759

Purpose: Anti-Cullin 4a/CUL4A Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human Cullin 4a recombinant protein (Position: M494-A759).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Cullin 4A

Target: Cullin 4A (CUL4A)

Alternative Name: CUL4A

Background:

Background: Cullin-4A is a protein that in humans is encoded by the CUL4A gene. It belongs to the cullin family of ubiquitin ligase proteins and is highly homologous to the CUL4B protein. CUL4A regulates numerous key processes such as DNA repair, chromatin remodeling, spermatogenesis, haematopoiesis and the mitotic cell cycle. As a result, CUL4A has been implicated in several cancers and the pathogenesis of certain viruses including HIV. Interestingly, a component of a CUL4A complex, Cereblon, was discovered to be a major target of the teratogenic agent thalidomide.

Gene Full Name: cullin 4A

Gene ID: 8451

UniProt: Q13619