LY86 antibody (AA 65-162)

Catalog No. ABIN748733

Product Details anti-LY86 Antibody

Target: LY86 (Lymphocyte Antigen 86 (LY86))

Binding Specificity: AA 65-162

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LY86 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human LY-86

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for LY86

Target: LY86 (Lymphocyte Antigen 86 (LY86))

Alternative Name: MD1 (LY86 Products)

Synonyms: MD-1 antibody, MMD-1 antibody, dJ80N2.1 antibody, MD1 antibody, LY86 antibody, lymphocyte antigen 86 antibody, LY86 antibody, Ly86 antibody

Background:

Synonyms: BPAD, dJ80N2.1, LY86, LY-86, LY 86, Lymphocyte antigen 86, Lymphocyte antigen 86 precursor, Major affective disorder 1, MD-1, MD1, MD 1, MD1 protein, MD1 RP105 associated, MD1 RP105 associated, MMD-1, RP1-80N2.1.

Background: MD1 is a 28 kDa molecule that is associated at the cell surface with RP105 (CD180). RP105 is a leucine-rich repeat (LRR) molecule that is expressed on B lymphocytes. It was first identified by a mAb that protects spleen B cells from irradiation-induced apoptosis. LRR proteins, such as Toll receptors, have a role in innate immunity. MD1 is primarily expressed by B cells, dendritic cells and monocytes, and promotes the recognition of, and subsequent signaling by LPS in the innate immune system. MD1 does not have any homology to other molecules. MD1 when expressed alone behaves as a secretory protein. Expression of MD1 in a cell increases the expression of RP105.

Gene ID: 9450

Pathways: Toll-Like Receptors Cascades