DDX58 antibody (AA 203-925) (Cy3)

Catalog No. ABIN7984275

This Rabbit Polyclonal antibody specifically detects DDX58 in FACS. It exhibits reactivity toward Human.

Quick Overview for DDX58 antibody (AA 203-925) (Cy3) (ABIN7984275)

Target: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDX58 antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-DDX58 Antibody (Cy3)

Binding Specificity: AA 203-925

Purpose: Anti-DDX58/RIG-1 Antibody Cy3 Conjugated

Cross-Reactivity (Details): No cross reactivity with other proteins.

Predicted Reactivity: Human RIGI shares 78.2% amino acid (aa) sequence identity with mouse RIGI.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human DDX58/RIG-1 recombinant protein (Position: K203-K925). Human RIGI shares 78.2% amino acid (aa) sequence identity with mouse RIGI.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for DDX58

Target: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Alternative Name: RIGI

Background:

Background: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2.

Gene Full Name: RNA sensor RIG-I

Gene ID: 23586

UniProt: O95786

Pathways: Activation of Innate immune Response, Hepatitis C