Desmoglein 2 antibody (AA 24-1020) (Fluoro647)

Catalog No. ABIN7984997

The Fluoro647-conjugated Mouse Monoclonal anti-Desmoglein 2 antibody (Clone 2B4D1) (ABIN7984997) specifically detects Desmoglein 2 in FACS. The antibody is reactive with Human samples.

Quick Overview for Desmoglein 2 antibody (AA 24-1020) (Fluoro647) (ABIN7984997)

Target: Desmoglein 2 (DSG2)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Desmoglein 2 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Clone: 2B4D1

Product Details anti-Desmoglein 2 Antibody (Fluoro647)

Binding Specificity: AA 24-1020

Purpose: Anti-Desmoglein 2/DSG2 Antibody (monoclonal, 2B4D1) Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Desmoglein 2/DSG2 recombinant protein (Position: L24-E1020).

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Desmoglein 2

Target: Desmoglein 2 (DSG2)

Alternative Name: DSG2

Background:

Background: Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in DSG2 display a high degree of penetrance. Disease expression was of variable severity with LV involvement a prominent feature. The low prevalence of classical ECG changes highlights the need to expand current diagnostic criteria to take account of LV disease, childhood disease expression, and incomplete penetrance.

Gene Full Name: desmoglein 2

Gene ID: 1829

UniProt: Q14126

Pathways: Cell-Cell Junction Organization