Desmoglein 2 antibody (AA 24-1020)

Catalog No. ABIN7984998

This Mouse Monoclonal antibody specifically detects Desmoglein 2 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for Desmoglein 2 antibody (AA 24-1020) (ABIN7984998)

Target: Desmoglein 2 (DSG2)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Desmoglein 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Grade: Carrier-free

Clone: 2B4D1

Product Details anti-Desmoglein 2 Antibody

Binding Specificity: AA 24-1020

Purpose: Anti-Desmoglein 2/DSG2 Antibody (monoclonal, 2B4D1)

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Desmoglein 2/DSG2 Antibody.(monoclonal, 2B4D1)-2. Tested in IHC, WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Desmoglein 2/DSG2 recombinant protein (Position: L24-E1020).

Isotype: IgG1

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Desmoglein 2

Target: Desmoglein 2 (DSG2)

Alternative Name: DSG2

Background:

Background: Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in DSG2 display a high degree of penetrance. Disease expression was of variable severity with LV involvement a prominent feature. The low prevalence of classical ECG changes highlights the need to expand current diagnostic criteria to take account of LV disease, childhood disease expression, and incomplete penetrance.

Gene Full Name: desmoglein 2

Molecular Weight: 160 kDa

Gene ID: 1829

UniProt: Q14126

Pathways: Cell-Cell Junction Organization