DKK2 antibody (AA 34-259) (Fluoro647)

Catalog No. ABIN7985176

The Rabbit Polyclonal anti-DKK2 antibody is suitable to detect DKK2 in samples from Human and Rat. It has been validated for FACS.

Quick Overview for DKK2 antibody (AA 34-259) (Fluoro647) (ABIN7985176)

Target: DKK2 (Dickkopf 2 Homolog (DKK2))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DKK2 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-DKK2 Antibody (Fluoro647)

Binding Specificity: AA 34-259

Purpose: Anti-DKK2 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human DKK2 shares 96% amino acid (aa) sequence identity with mouse DKK2.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human DKK2 recombinant protein (Position: K34-I259). Human DKK2 shares 96% amino acid (aa) sequence identity with mouse DKK2.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for DKK2

Target: DKK2 (Dickkopf 2 Homolog (DKK2))

Alternative Name: DKK2

Background:

Background: Dickkopf-related protein 2 is a protein that in humans is encoded by the DKK2 gene. This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).

Gene Full Name: dickkopf Wnt signaling pathway inhibitor 2

Sequence Similarities: Belongs to the DAXX family.

Gene ID: 27123

UniProt: Q9UBU2

Pathways: WNT Signaling