DKK1 antibody (AA 73-272) (Fluoro488)

Catalog No. ABIN7985191

The Rabbit Polyclonal anti-DKK1 antibody is suitable to detect DKK1 in samples from Rat and Mouse. It has been validated for FACS.

Quick Overview for DKK1 antibody (AA 73-272) (Fluoro488) (ABIN7985191)

Target: DKK1 (Dickkopf Homolog 1 (DKK1))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DKK1 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-DKK1 Antibody (Fluoro488)

Binding Specificity: AA 73-272

Purpose: Anti-Dkk1 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Dkk1 recombinant protein (Position: N73-H272).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for DKK1

Target: DKK1 (Dickkopf Homolog 1 (DKK1))

Alternative Name: Dkk1

Background:

Background: DKK1, Dickkopf-related protein 1, is a protein that in humans is encoded by the DKK1 gene. This gene encodes a protein that is a member of the dickkopf family. By genomic sequence analysis, determined that the DKK1 gene contains 4 exons. The DKK1 gene is mapped to 10q11.2 using FISH. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

Gene Full Name: dickkopf WNT signaling pathway inhibitor 1

Gene ID: 13380

UniProt: O54908

Pathways: WNT Signaling, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation