DGCR8 antibody (AA 561-762) (Cy3)

Catalog No. ABIN7985236

The Rabbit Polyclonal anti-DGCR8 antibody is suitable to detect DGCR8 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for DGCR8 antibody (AA 561-762) (Cy3) (ABIN7985236)

Target: DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DGCR8 antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-DGCR8 Antibody (Cy3)

Binding Specificity: AA 561-762

Purpose: Anti-DGCR8 Antibody Cy3 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived human DGCR8 recombinant protein (Position: K561-Q762).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for DGCR8

Target: DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))

Alternative Name: DGCR8

Background:

Background: The DGCR8 microprocessor complex subunit (DiGeorge syndrome chromosomal [or critical] region 8) is a protein that in humans is encoded by the DGCR8 gene. This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants.

Gene Full Name: DGCR8 microprocessor complex subunit

Gene ID: 54487

UniProt: Q8WYQ5

Pathways: Regulatory RNA Pathways