DLG1 antibody (AA 1-165) (PE)

Catalog No. ABIN7985637

This Rabbit Polyclonal antibody specifically detects DLG1 in FACS. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for DLG1 antibody (AA 1-165) (PE) (ABIN7985637)

Target: DLG1 (Discs, Large Homolog 1 (DLG1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLG1 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-DLG1 Antibody (PE)

Binding Specificity: AA 1-165

Purpose: Anti-SAP97/DLG1 Antibody PE Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human SAP97 shares 89.7%,84.2% amino acid (aa) sequence identity with mouse,rat SAP97,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SAP97 recombinant protein (Position: M1-A165). Human SAP97 shares 89.7% and 84.2% amino acid (aa) sequence identity with mouse and rat SAP97, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for DLG1

Target: DLG1 (Discs, Large Homolog 1 (DLG1))

Alternative Name: DLG1

Background:

Background: Disks large homolog 1 (DLG1), also known as synapse-associated protein 97 or SAP97, is a protein that in humans is encoded by the SAP97 gene. SAP97 is expressed throughout the body in epithelial cells, including the kidney and brain. There is some evidence that SAP97 regulates cell-to-cell adhesion during cell death, and may interact with HPV. In the brain, SAP97's function is involved in the trafficking of transmembrane receptors from the ER to the plasma membrane. SAP97's function has been investigated by reducing its expression by knockout or increasing its expression heterologously. Mice in which the SAP97 gene has been knocked out die perinatally, have a cleft palate, and deficiencies in renal function. Overexpression of SAP97 in mammalian neurons leads to increased synaptic strength.

Gene Full Name: discs large MAGUK scaffold protein 1

Sequence Similarities: Belongs to the MAGUK family.

Gene ID: 1739

UniProt: Q12959

Pathways: Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response