SPTAN1 antibody (AA 551-650) (Biotin)

Catalog No. ABIN748945

Product Details anti-SPTAN1 Antibody (Biotin)

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Binding Specificity: AA 551-650

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPTAN1 antibody is conjugated to Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SPECA

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for SPTAN1

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Alternative Name: SPECA (SPTAN1 Products)

Background:

Synonyms: Fodrin alpha chain, ALPHAII-SPECTRIN, Alpha II Spectrin, FLJ44613, Fodrin, alpha, NEAS, Non erythrocytic spectrin alpha, SPECA, Spectrin alpha chain, Spectrin alpha chain brain, Spectrin alpha non erythrocytic 1, Spectrin non erythroid alpha chain, Spectrin, alpha, non-erythrocytic 1 alpha-fodrin, Spectrin, nonerythroid, alpha subunit, Spna2, SPTA 2, SPTA2, SPTAN 1, SPTAN1, SPTA1_HUMAN.

Background: a-Fodrin is a universally expressed membrane associated cytoskeletal protein consisting of alpha and beta subunits. The protein is important for maintaining normal membrane structure and supporting cell surface protein function. Alpha Fodrin is one of the important targets cleaved by caspases during apoptosis. The full length 240 kDa protein can be cleaved at several sites within its sequence by activated caspases generating N terminal 150 kDa, C terminal 120 kDa, and 35 kDa major products. Cleavage of alpha Fodrin leads to membrane malfunction and cell shrinkage.

Gene ID: 5795

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization