Dysferlin antibody (AA 51-747) (Fluoro647)

Catalog No. ABIN7986677

The Fluoro647-conjugated Rabbit Polyclonal anti-Dysferlin antibody (ABIN7986677) specifically detects Dysferlin in FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Dysferlin antibody (AA 51-747) (Fluoro647) (ABIN7986677)

Target: Dysferlin (DYSF)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dysferlin antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-Dysferlin Antibody (Fluoro647)

Binding Specificity: AA 51-747

Purpose: Anti-Dysferlin/DYSF Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human DYSF recombinant protein (Position: E51-H747).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Dysferlin

Target: Dysferlin (DYSF)

Alternative Name: DYSF

Background:

Background: Dysferlin also known as dystrophy-associated fer-1-like protein is a protein that in humans is encoded by the DYSF gene. The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Alternative splicing results in multiple transcript variants.

Gene Full Name: dysferlin

Gene ID: 8291

UniProt: O75923