NSMCE2 antibody (AA 14-228) (Fluoro647)

Catalog No. ABIN7986919

The Rabbit Polyclonal anti-NSMCE2 antibody is suitable to detect NSMCE2 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for NSMCE2 antibody (AA 14-228) (Fluoro647) (ABIN7986919)

Target: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NSMCE2 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-NSMCE2 Antibody (Fluoro647)

Binding Specificity: AA 14-228

Purpose: Anti-NSMCE2 Antibody Fluoro647 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NSMCE2 recombinant protein (Position: F14-D228).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for NSMCE2

Target: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Alternative Name: NSMCE2

Background:

Background: This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. A knockout of the orthologous mouse gene is lethal prior to embryonic day 10.5. Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance.

Gene Full Name: NSE2 SUMO ligase component of SMC5/6 complex

Gene ID: 286053

UniProt: Q96MF7