NFAM1 antibody (AA 81-180)

Catalog No. ABIN749033

There are 2+ publications for this product available. The Rabbit Polyclonal anti-NFAM1 antibody is suitable to detect NFAM1 in samples from Human, Mouse and Rat. It has been validated for ELISA, WB, IF (cc), IF (p), IHC (fro), IHC (p) and ICC.

Quick Overview for NFAM1 antibody (AA 81-180) (ABIN749033)

Target: NFAM1 (NFAT Activating Protein with ITAM Motif 1 (NFAM1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFAM1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Product Details anti-NFAM1 Antibody

Binding Specificity: AA 81-180

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NFAM1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-NFAM1 antibody (ABIN749033)

Sambandam, Sundaram, Saigusa, Balasubramanian, Reddy: "NFAM1 signaling enhances osteoclast formation and bone resorption activity in Paget's disease of bone." in: Bone, Vol. 101, pp. 236-244, (2018) (PubMed).

Target Details for NFAM1

Target: NFAM1 (NFAT Activating Protein with ITAM Motif 1 (NFAM1))

Alternative Name: NFAM1

Background:

Synonyms: CNAIP, bK126B4.4, NFAT activation molecule 1, Calcineurin/NFAT-activating ITAM-containing protein, NFAT-activating protein with ITAM motif 1, NFAM1

Background: May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.

Gene ID: 150372

UniProt: Q8NET5