ELP3/KAT9 antibody (C-Term) (Fluoro488)

Catalog No. ABIN7987401

This Mouse Monoclonal antibody specifically detects ELP3/KAT9 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ELP3/KAT9 antibody (C-Term) (Fluoro488) (ABIN7987401)

Target: ELP3/KAT9 (ELP3) (Elongator complex protein 3 (ELP3))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This ELP3/KAT9 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Clone: 8B4

Product Details anti-ELP3/KAT9 Antibody (Fluoro488)

Binding Specificity: C-Term

Purpose: Anti-KAT9/ELP3 Antibody (monoclonal, 8B4) Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: identical to the related mouse sequence.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human KAT9/ELP3, identical to the related mouse sequence.

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for ELP3/KAT9

Target: ELP3/KAT9 (ELP3) (Elongator complex protein 3 (ELP3))

Alternative Name: ELP3

Background:

Background: Elongator complex protein 3, also named KAT9, is aproteinthat in humans is encoded by theELP3gene. It is mapped to 8p21.1. ELP3 is the catalytichistone acetyltransferasesubunit of theRNA polymeraseII elongator complex, which is a component of the RNA polymerase II (Pol II)holoenzymeand is involved in transcriptional elongation. ELP3 supports the migration and branching ofprojection neuronsthroughacetylationof alpha-tubulin in the developingcerebral cortex. In mammals, ELP3 is important for paternalDNA demethylationafterfertilization.ELP3 is potentially involved in cellular redoxhomeostasisby mediating the acetylation ofglucose-6-phosphate dehydrogenase. Besides, ELP3 may play a role inchromatin remodelingand is involved in acetylation ofhistones H3and probablyH4.

Gene Full Name: elongator acetyltransferase complex subunit 3

Gene ID: 55140

UniProt: Q9H9T3