EVL antibody (AA 268-400) (Biotin)

Catalog No. ABIN7987476

This Rabbit Polyclonal antibody specifically detects EVL in WB, ELISA and IHC. It exhibits reactivity toward Human.

Quick Overview for EVL antibody (AA 268-400) (Biotin) (ABIN7987476)

Target: EVL (Ena-Vasodilator Stimulated Phosphoprotein (EVL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EVL antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-EVL Antibody (Biotin)

Binding Specificity: AA 268-400

Purpose: Anti-EVL Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human EVL recombinant protein (Position: M268-E400).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for EVL

Target: EVL (Ena-Vasodilator Stimulated Phosphoprotein (EVL))

Alternative Name: EVL

Background:

Background: Ena/VASP-like protein is a member of the Ena/VASP family of proteins that in humans is encoded by the EVL gene. Ena/VASP-like (EVL) protein is a member of the Ena/VASP family and is involved in actin-associated cytoskeleton remodeling and cell polarity activities including axon guidance and lamellipodia formation in migrating cells. The EVL protein sequence contains an N-terminal EVH1 domain, a Pro-rich SH3 binding domain, and a C-terminal EVH2 domain. EVL domain interactions with G- and F-actin mediates actin nucleation and polymerization. Research studies have shown that EVL also regulates DNA repair by interaction with RAD51. EVL may function in the DSB repair pathway through the EVH2 domain, which possesses DNA-binding and RAD51 binding activity, thereby coordinating homologous DNA recombination. Research studies have shown EVL expression is up-regulated in human breast cancer associated with clinical stages and may be implicated in invasion and/or metastasis of human breast cancer.

Gene Full Name: Enah/Vasp-like

Gene ID: 51466

UniProt: Q9UI08