SH3G2 antibody (AA 65-292) (PE)

Catalog No. ABIN7987595

The PE-conjugated Mouse Monoclonal anti-SH3G2 antibody (Clone 6I8E1) (ABIN7987595) specifically detects SH3G2 in FACS. The antibody is reactive with Mouse and Rat samples.

Quick Overview for SH3G2 antibody (AA 65-292) (PE) (ABIN7987595)

Target: SH3G2 (Endophilin-A1 (SH3G2))

Reactivity: Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This SH3G2 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: 6I8E1

Product Details anti-SH3G2 Antibody (PE)

Binding Specificity: AA 65-292

Purpose: Anti-SH3GL2 Antibody (monoclonal, 6I8E1) PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human SH3GL2 recombinant protein (Position: R65-Q292).

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for SH3G2

Target: SH3G2 (Endophilin-A1 (SH3G2))

Alternative Name: SH3GL2

Background:

Background: Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene. Endophilin proteins are part of a large family of Bin/Amphiphysin/Rvs (BAR) domain proteins that are involved in cell membrane remodeling. The endophilins are encoded by five genes, which produce endophilin A 1-3 and B 1-2. Endophilins are involved in many cellular mechanisms, such as synaptic vesicle recycling, receptor trafficking, and membrane remodeling processes. Research studies indicate that endophilin 1 (endophilin A1, SH3GL2) can induce different membrane shapes and participate in the morphogenesis of dendritic spines. Endophilin 1 is also involved in regulating blood brain barrier permeability via the EGFR-JNK pathway.

Gene Full Name: SH3 domain containing GRB2 like 2, endophilin A1

Gene ID: 6456

UniProt: Q99962

Pathways: Neurotrophin Signaling Pathway, EGFR Downregulation