ECE1 antibody (AA 18-233) (Fluoro647)

Catalog No. ABIN7987773

This Rabbit Polyclonal antibody specifically detects ECE1 in FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ECE1 antibody (AA 18-233) (Fluoro647) (ABIN7987773)

Target: ECE1 (Endothelin-Converting Enzyme 1 (ECE1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ECE1 antibody is conjugated to Fluoro647

Application: Flow Cytometry (FACS)

Product Details anti-ECE1 Antibody (Fluoro647)

Binding Specificity: AA 18-233

Purpose: Anti-ECE1 Antibody Fluoro647 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human ECE1 shares 94%,93.5% amino acid (aa) sequence identity with mouse,rat ECE1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human ECE1 recombinant protein (Position: M18-T233). Human ECE1 shares 94% and 93.5% amino acid (aa) sequence identity with mouse and rat ECE1, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for ECE1

Target: ECE1 (Endothelin-Converting Enzyme 1 (ECE1))

Alternative Name: ECE1

Background:

Background: Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene. The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Gene Full Name: endothelin converting enzyme 1

Gene ID: 1889

UniProt: P42892

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling