EDC4 antibody (AA 1082-1388) (Biotin)

Catalog No. ABIN7987775

The Biotin-conjugated Rabbit Polyclonal anti-EDC4 antibody (ABIN7987775) specifically detects EDC4 in ELISA, WB and IHC. The antibody is reactive with Human samples.

Quick Overview for EDC4 antibody (AA 1082-1388) (Biotin) (ABIN7987775)

Target: EDC4 (Enhancer of mRNA Decapping 4 (EDC4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EDC4 antibody is conjugated to Biotin

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-EDC4 Antibody (Biotin)

Binding Specificity: AA 1082-1388

Purpose: Anti-EDC4 Antibody Biotin Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human EDC4 recombinant protein (Position: K1082-L1388).

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for EDC4

Target: EDC4 (Enhancer of mRNA Decapping 4 (EDC4))

Alternative Name: EDC4

Background:

Background: Enhancer of mRNA-decapping protein 4 is a protein that in humans is encoded by the EDC4 gene. Enhancer of mRNA decapping 4 (EDC4) was originally identified as the autoantigen Ge-1 from a Sjgren's syndrome patient later diagnosed with primary biliary cirrhosis. EDC4 (also known as HEDLS) was later identified as an essential component of cytoplasmic P-bodies responsible for mRNA decapping and degradation. Identified EDC4 protein is found as a pair of isoforms generated by alternative splicing and contains several WD domains and a putative nuclear localization signal. EDC4 co-localizes with other P-body decapping proteins such as DCP1A, DCP2 and GW182. Experimental evidence suggests that EDC4 may be involved in miRNA-mediated translation repression.

Gene Full Name: enhancer of mRNA decapping 4

Gene ID: 23644

UniProt: Q6P2E9