Plexin A1 antibody (PE)

Catalog No. ABIN749223

This anti-Plexin A1 antibody is a Rabbit Polyclonal antibody detecting Plexin A1 in FACS. Suitable for Human, Mouse and Rat.

Quick Overview for Plexin A1 antibody (PE) (ABIN749223)

Target: Plexin A1 (PLXNA1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Plexin A1 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-Plexin A1 Antibody (PE)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Plexin A1

Isotype: IgG

Application Details

Application Notes: FCM: 1:20-100
Optimal working dilution should be determined by the investigator.

Comment:

Exitation/Emission: 480,565nm/578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4 °C

Expiry Date: 12 months

Target Details for Plexin A1

Target: Plexin A1 (PLXNA1)

Alternative Name: Plexin A1

Background:

Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contain a semaphorin domain, multiple glycine rich motifs, and MET related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites that mediate signal transduction after activation. This region in Plexin A1 binds the RhoGTPases, Rnd1 and RhoD. Recruitment of Rnd1 has been implicated in the cytoskeletal collapse that occurs after semaphorin mediated activation of Plexin A1, while RhoD may block this collapsing activity through interaction with the cytoplasmic region of Plexin A1. The expression of Plexin A1, along with the co receptor Neuropilin 1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin A1 and Neuropilin 1, may have significant roles in axon regeneration after neuronal injury.

Subcellular location: Extracellular

Synonyms: NOV, NOV/plexin A1 protein, NOVP, Plexin1, PlexinA1, PLXN1, PLXNA1, PLXNA1, protein, Semaphorin receptor NOV, PLXA1_HUMAN.

Gene ID: 5361

Pathways: Smooth Muscle Cell Migration