FBXW8 antibody (AA 1-598) (PE)

Catalog No. ABIN7989461

The PE-conjugated Rabbit Polyclonal anti-FBXW8 antibody (ABIN7989461) specifically detects FBXW8 in FACS. The antibody is reactive with Human and Rat samples.

Quick Overview for FBXW8 antibody (AA 1-598) (PE) (ABIN7989461)

Target: FBXW8 (F-Box and WD Repeat Domain Containing 8 (FBXW8))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXW8 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-FBXW8 Antibody (PE)

Binding Specificity: AA 1-598

Purpose: Anti-FBXW8 Antibody PE Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human FBXW8 shares 78.5%,77.4% amino acid (aa) sequence identity with mouse,rat FBXW8,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human FBXW8 recombinant protein (Position: M1-V598). Human FBXW8 shares 78.5% and 77.4% amino acid (aa) sequence identity with mouse and rat FBXW8, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for FBXW8

Target: FBXW8 (F-Box and WD Repeat Domain Containing 8 (FBXW8))

Alternative Name: FBXW8

Background:

Background: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Gene Full Name: F-box and WD repeat domain containing 8

Gene ID: 26259

UniProt: Q8N3Y1