FER antibody (Middle Region) (Cy3)

Catalog No. ABIN7990236

This Rabbit Polyclonal antibody specifically detects FER in FACS. It exhibits reactivity toward Human and Rat.

Quick Overview for FER antibody (Middle Region) (Cy3) (ABIN7990236)

Target: FER (FER Tyrosine Kinase (FER))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FER antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-FER Antibody (Cy3)

Binding Specificity: Middle Region

Purpose: Anti-Tyrosine-protein kinase Fer FER Antibody Cy3 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related rat,mouse sequences by two amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human FER, different from the related rat and mouse sequences by two amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for FER

Target: FER (FER Tyrosine Kinase (FER))

Alternative Name: FER

Background:

Background: FER (FPS/FES-Related tyrosine kinase) also known as TYK3, is an enzyme that in humans is encoded by the FER gene. Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. By in situ hybridization, Morris et al. (1990) concluded that the FER gene is located at 5q21-q22. Treatment of cells with JMP resulted in the release of FER from the cadherin complex and its accumulation in the integrin complex. The accumulation of FER in the integrin complex and the inhibitory effects of JMP could be reversed with a peptide that mimics the first coiled-coil domain of FER. The results suggested that FER mediates crosstalk between CDH2 and ITGB1. In Fer mutant mice, leukocyte emigration was exaggerated in response to LPS without altering vascular permeability, suggesting that FER has a role in regulating innate immunity.

Gene Full Name: FER tyrosine kinase

Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.

Gene ID: 2241

UniProt: P16591