Filamin A antibody (AA 451-638) (HRP)

Catalog No. ABIN7990881

This Mouse Monoclonal antibody specifically detects Filamin A in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for Filamin A antibody (AA 451-638) (HRP) (ABIN7990881)

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Filamin A antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 3F8

Product Details anti-Filamin A Antibody (HRP)

Binding Specificity: AA 451-638

Purpose: Anti-Filamin A/FLNA Antibody (monoclonal, 3F8) HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Filamin A/FLNA recombinant protein (Position: E451-Q638).

Isotype: IgG1

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Filamin A

Target: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Alternative Name: FLNA

Background:

Background: Filamin A, alpha (FLNA) is a protein that in humans is encoded by the FLNA gene. It is mapped to Xq28. The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.

Gene Full Name: filamin A

UniProt: P21333

Pathways: TCR Signaling, Maintenance of Protein Location