FOXM1 antibody (AA 48-763) (Fluoro488)

Catalog No. ABIN7991482

The Rabbit Polyclonal anti-FOXM1 antibody is suitable to detect FOXM1 in samples from Human, Rat and Mouse. It has been validated for FACS.

Quick Overview for FOXM1 antibody (AA 48-763) (Fluoro488) (ABIN7991482)

Target: FOXM1 (Forkhead Box M1 (FOXM1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXM1 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-FOXM1 Antibody (Fluoro488)

Binding Specificity: AA 48-763

Purpose: Anti-FOXM1 Antibody Fluoro488 Conjugated

Predicted Reactivity: Human FOXM1 shares 78.9%,81.1% amino acid (aa) sequence identity with mouse,rat FOXM1,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human FOXM1 recombinant protein (Position: K48-Q763). Human FOXM1 shares 78.9% and 81.1% amino acid (aa) sequence identity with mouse and rat FOXM1, respectively.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for FOXM1

Target: FOXM1 (Forkhead Box M1 (FOXM1))

Alternative Name: FOXM1

Background:

Background: Forkhead box protein M1, also called FOXM1, is a protein that in humans is encoded by the FOXM1 gene. It is mapped to 12p13.33. The protein encoded by this gene is a member of the FOX family of transcription factors. FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases and also in the control of cell proliferation. FOXM1 gene is now known as a human proto-oncogene. Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide. It was hypothesized that FOXM1 induces cancer initiation through stem/progenitor cell expansion. What's more, FOXM1 has been shown to modulate the epigenome. It was found that overexpression of FOXM1 brain washes normal cells to adopt cancer-like epigenome.

Gene Full Name: forkhead box M1

Gene ID: 2305

UniProt: Q08050

Pathways: Positive Regulation of Response to DNA Damage Stimulus