GATA3 antibody (AA 1-197) (PE)

Catalog No. ABIN7992946

The Rabbit Polyclonal anti-GATA3 antibody is suitable to detect GATA3 in samples from Human and Rat. It has been validated for FACS.

Quick Overview for GATA3 antibody (AA 1-197) (PE) (ABIN7992946)

Target: GATA3 (GATA Binding Protein 3 (GATA3))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GATA3 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-GATA3 Antibody (PE)

Binding Specificity: AA 1-197

Purpose: Anti-GATA3 Antibody PE Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human GATA3 shares 95% amino acid (aa) sequence identity with mouse GATA3.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human GATA3 recombinant protein (Position: M1-E197). Human GATA3 shares 95% amino acid (aa) sequence identity with mouse GATA3.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for GATA3

Target: GATA3 (GATA Binding Protein 3 (GATA3))

Alternative Name: GATA3

Background:

Background: Trans-acting T-cell-specific transcription factor GATA-3, also named HDR or GATA3, is a protein that in humans is encoded by the GATA3 gene. It is mapped to 10p14. This gene belongs to the GATA family of transcription factors. It regulates luminal epithelial cell differentiation in the mammary gland. The protein contains two GATA-type zinc fingers, it is an important regulator of T cell development and plays an important role in endothelial cell biology. GATA3 has been shown to promote the secretion of IL-4, IL-5, and IL-13 from Th2 cells, and induces the differentiation of Th0 cells towards this T cell subtype while suppressing their differentiation towards Th1 cells.

Gene Full Name: GATA binding protein 3

Sequence Similarities: Contains 2 GATA-type zinc fingers.

Gene ID: 2625

UniProt: P23771

Pathways: Hormone Transport, Regulation of Hormone Metabolic Process, Tube Formation