GFRA1 antibody (AA 25-227) (PE)

Catalog No. ABIN7993023

This Rabbit Polyclonal antibody specifically detects GFRA1 in FACS. It exhibits reactivity toward Human.

Quick Overview for GFRA1 antibody (AA 25-227) (PE) (ABIN7993023)

Target: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GFRA1 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-GFRA1 Antibody (PE)

Binding Specificity: AA 25-227

Purpose: Anti-GDNF Receptor alpha 1/GFRA1 Antibody PE Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human GFRA1 shares 97% amino acid (aa) sequence identity with both mouse,rat GFRA1.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human GFRA1 recombinant protein (Position: D25-Q227). Human GFRA1 shares 97% amino acid (aa) sequence identity with both mouse and rat GFRA1.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for GFRA1

Target: GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))

Alternative Name: GFRA1

Background:

Background: GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor or GFRA1, is a protein that in humans is encoded by the GFRA1 gene. It is mapped to chromosome 10q25.3. The protein encoded by this gene is a member of the GDNF receptor family. GFRA1 is released by neuronal cells, Schwann cells, and injured sciatic nerve. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is also a candidate gene for Hirschsprung disease. Soluble GFRA1 mediates robust recruitment of RET to lipid rafts via a mechanism requiring the RET tyrosine kinase.

Gene Full Name: GDNF family receptor alpha 1

Sequence Similarities: Belongs to the glutamate--cysteine ligase type 3 family.

Gene ID: 14585

UniProt: P56159