TREM2 antibody (AA 1-100)

Catalog No. ABIN749678

The Rabbit Polyclonal anti-TREM2 antibody has been validated for WB, ELISA, ICC, IHC (p), IHC (fro), IF (p) and IF (cc). It is suitable to detect TREM2 in samples from Mouse, Human, Rat and Pig. There are 3+ publications available.

Quick Overview for TREM2 antibody (AA 1-100) (ABIN749678)

Target: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Reactivity: Mouse, Human, Rat, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TREM2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Product Details anti-TREM2 Antibody

Binding Specificity: AA 1-100

Cross-Reactivity: Human, Mouse, Pig, Rat

Predicted Reactivity: Dog,Cow,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TREM2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-TREM2 antibody (ABIN749678)

Abdi, Pasbakhsh, Shabani, Nekoonam, Sadeghi, Fathi, Abouzaripour, Mohamed, Zibara, Kashani, Zendedel: "Metformin Therapy Attenuates Pro-inflammatory Microglia by Inhibiting NF-κB in Cuprizone Demyelinating Mouse Model of Multiple Sclerosis." in: Neurotoxicity research, (2021) (PubMed).

Rai, Dietz, Dilisio, Radwan, Agrawal: "Vitamin D attenuates inflammation, fatty infiltration, and cartilage loss in the knee of hyperlipidemic microswine." in: Arthritis research & therapy, Vol. 18, Issue 1, pp. 203, (2016) (PubMed).

Satoh, Kawana, Yamamoto, Ishida, Saito, Arima: "A survey of TREM2 antibodies reveals neuronal but not microglial staining in formalin-fixed paraffin-embedded postmortem Alzheimer's brain tissues." in: Alzheimer's research & therapy, Vol. 5, Issue 4, pp. 30, (2014) (PubMed).

Target Details for TREM2

Target: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Alternative Name: TREM2

Background:

Synonyms: TREM-2, Trem2a, Trem2b, Trem2c, Triggering receptor expressed on myeloid cells 2, Triggering receptor expressed on monocytes 2, TREM2

Background: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.

Gene ID: 54209

UniProt: Q9NZC2