GPT2 antibody (AA 56-523) (Fluoro488)

Catalog No. ABIN7993954

The Rabbit Polyclonal anti-GPT2 antibody is suitable to detect GPT2 in samples from Human, Mouse and Rat. It has been validated for FACS.

Quick Overview for GPT2 antibody (AA 56-523) (Fluoro488) (ABIN7993954)

Target: GPT2 (Glutamic Pyruvate Transaminase (Alanine Aminotransferase) 2 (GPT2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPT2 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Product Details anti-GPT2 Antibody (Fluoro488)

Binding Specificity: AA 56-523

Purpose: Anti-GPT2 Antibody Fluoro488 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Human GPT2 shares 94.4% amino acid (aa) sequence identity with mouse GPT2.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human GPT2 recombinant protein (Position: Q56-A523). Human GPT2 shares 94.4% amino acid (aa) sequence identity with mouse GPT2.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for GPT2

Target: GPT2 (Glutamic Pyruvate Transaminase (Alanine Aminotransferase) 2 (GPT2))

Alternative Name: GPT2

Background:

Background: This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants.

Gene Full Name: glutamic--pyruvic transaminase 2

Gene ID: 84706

UniProt: Q8TD30