GSTA3 antibody (N-Term) (HRP)

Catalog No. ABIN7994256

This Rabbit Polyclonal antibody specifically detects GSTA3 in WB, IHC and ELISA. It exhibits reactivity toward Mouse and Rat.

Quick Overview for GSTA3 antibody (N-Term) (HRP) (ABIN7994256)

Target: GSTA3 (Glutathione S-Transferase alpha 3 (GSTA3))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSTA3 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-GSTA3 Antibody (HRP)

Binding Specificity: N-Term

Purpose: Anti-Gsta3 Antibody HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of mouse Gsta3, which shares 57.9% and 89.5% amino acid (aa) sequence identity with human and rat Gsta3, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GSTA3

Target: GSTA3 (Glutathione S-Transferase alpha 3 (GSTA3))

Alternative Name: Gsta3

Background:

Background: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined.

Gene Full Name: glutathione S-transferase, alpha 3

Gene ID: 2940

UniProt: P30115