ULBP1 antibody

Catalog No. ABIN749753

The Rabbit Polyclonal anti-ULBP1 antibody is suitable to detect ULBP1 in samples from Human. It has been validated for IHC (p).

Quick Overview for ULBP1 antibody (ABIN749753)

Target: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ULBP1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ULBP1 Antibody

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ULBP1

Isotype: IgG

Application Details

Application Notes: WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ULBP1

Target: ULBP1 (UL16 Binding Protein 1 (ULBP1))

Alternative Name: ULBP1

Background:

Synonyms: ALCAN-beta, N2DL-1, N2DL1, NKG2D ligand 1 precursor, NKG2DL1, RAET1I, Retinoic acid early transcript 1I, UL16, UL16 binding protein 1, UL16-binding protein 1, N2DL1_HUMAN.

Background: N2DL1 is a human rat mouse ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. The interaction with UL16 blocks the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. ULBP1 is expressed in T-cells, B-cells, erythroleukemia cell lines and in a wide range of tissues.

Gene ID: 80329

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process