GSTM2 antibody (Middle Region) (FITC)

Catalog No. ABIN7994332

The Rabbit Polyclonal anti-GSTM2 antibody is suitable to detect GSTM2 in samples from Human, Rat and Mouse. It has been validated for FACS.

Quick Overview for GSTM2 antibody (Middle Region) (FITC) (ABIN7994332)

Target: GSTM2 (Glutathione S-Transferase mu 2 (Muscle) (GSTM2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GSTM2 antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Product Details anti-GSTM2 Antibody (FITC)

Binding Specificity: Middle Region

Purpose: Anti-GSTM2 Antibody FITC Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: Mouse GSTM2 shares 72% amino acid (aa) sequence identity with both mouse,rat GSTM2.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human GSTM2. Mouse GSTM2 shares 72% amino acid (aa) sequence identity with both mouse and rat GSTM2.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for GSTM2

Target: GSTM2 (Glutathione S-Transferase mu 2 (Muscle) (GSTM2))

Alternative Name: GSTM2

Background:

Background: Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.

Gene Full Name: glutathione S-transferase mu 2

Gene ID: 2946

UniProt: P28161

Pathways: Negative Regulation of Transporter Activity