GLDC antibody (AA 574-1020) (HRP)

Catalog No. ABIN7994553

This Mouse Monoclonal antibody specifically detects GLDC in WB, IHC and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for GLDC antibody (AA 574-1020) (HRP) (ABIN7994553)

Target: GLDC (Glycine Dehydrogenase (GLDC))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This GLDC antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 3D3D3

Product Details anti-GLDC Antibody (HRP)

Binding Specificity: AA 574-1020

Purpose: Anti-Glycine decarboxylase/GLDC Antibody (monoclonal, 3D3D3) HRP Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Glycine decarboxylase/GLDC recombinant protein (Position: K574-S1020).

Isotype: IgG1

Application Details

Application Notes: Western blot, Optimal dilutions should be determined by end users. Immunohistochemistry (Paraffin-embedded Section), Optimal dilutions should be determined by end users. ELISA, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GLDC

Target: GLDC (Glycine Dehydrogenase (GLDC))

Alternative Name: GLDC

Background:

Background: Glycine decarboxylase also known as glycine cleavage system P protein or glycine dehydrogenase is an enzyme that in humans is encoded by the GLDC gene. Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).

Gene Full Name: glycine decarboxylase

Gene ID: 2731

UniProt: P23378