GLDC antibody (AA 574-1020)

Catalog No. ABIN7994557

The Mouse Monoclonal anti-GLDC antibody is suitable to detect GLDC in samples from Human, Mouse and Rat. It has been validated for WB and IHC.

Quick Overview for GLDC antibody (AA 574-1020) (ABIN7994557)

Target: GLDC (Glycine Dehydrogenase (GLDC))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This GLDC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Grade: Carrier-free

Clone: 3D3D3

Product Details anti-GLDC Antibody

Binding Specificity: AA 574-1020

Purpose: Anti-Glycine decarboxylase/GLDC Antibody (monoclonal, 3D3D3)

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-Glycine decarboxylase/GLDC Antibody.(monoclonal, 3D3D3). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human Glycine decarboxylase/GLDC recombinant protein (Position: K574-S1020).

Isotype: IgG1

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GLDC

Target: GLDC (Glycine Dehydrogenase (GLDC))

Alternative Name: GLDC

Background:

Background: Glycine decarboxylase also known as glycine cleavage system P protein or glycine dehydrogenase is an enzyme that in humans is encoded by the GLDC gene. Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).

Gene Full Name: glycine decarboxylase

Molecular Weight: 113 kDa

Gene ID: 2731

UniProt: P23378