GAB2 antibody (AA 162-504)

Catalog No. ABIN7995140

The Rabbit Polyclonal anti-GAB2 antibody (ABIN7995140) specifically detects GAB2 in WB, ELISA and FACS. The antibody is reactive with Human and Mouse samples.

Quick Overview for GAB2 antibody (AA 162-504) (ABIN7995140)

Target: GAB2 (GRB2-Associated Binding Protein 2 (GAB2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Grade: Carrier-free

Product Details anti-GAB2 Antibody

Binding Specificity: AA 162-504

Purpose: Anti-GAB2 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-GAB2 Antibody. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human, Mouse.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human GAB2 recombinant protein (Position: S162-R504).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.25 μg/mL, Human, Rat Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human ELISA, 0.1-0.5 μg/mL, -

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for GAB2

Target: GAB2 (GRB2-Associated Binding Protein 2 (GAB2))

Alternative Name: GAB2

Background:

Background: GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene. This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene

Gene Full Name: GRB2 associated binding protein 2

Molecular Weight: 90 kDa

Gene ID: 9846

UniProt: Q9UQC2

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, BCR Signaling, Warburg Effect