Haptoglobin antibody (Middle Region) (Fluoro550)

Catalog No. ABIN7996025

The Fluoro550-conjugated Rabbit Polyclonal anti-Haptoglobin antibody (ABIN7996025) specifically detects Haptoglobin in FACS. The antibody is reactive with Human samples.

Quick Overview for Haptoglobin antibody (Middle Region) (Fluoro550) (ABIN7996025)

Target: Haptoglobin (HP)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Haptoglobin antibody is conjugated to Fluoro550

Application: Flow Cytometry (FACS)

Product Details anti-Haptoglobin Antibody (Fluoro550)

Binding Specificity: Middle Region

Purpose: Anti-Haptoglobin/HP Antibody Fluoro550 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human Haptoglobin.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for Haptoglobin

Target: Haptoglobin (HP)

Alternative Name: HP

Background:

Background: Haptoglobin (HP), is a protein that in humans is encoded by the HP gene. Haptoglobin, a plasma glycoprotein that binds free hemoglobin, has a tetrameric structure of 2 alpha and 2 beta polypeptides that are covalently associated by disulfide bonds. Haptoglobin is homologous to serine proteases of the chymotrypsinogen family. In the chimpanzee, there are 3 genes in the haptoglobin family (haptoglobin, HP, haptoglobin-related, HPR, and haptoglobin-primate, HPP), whereas only 2 genes exist in humans (HP and HPR). There are similarities between the primary structures of the alpha chain and of light chains of gamma globulins. The alpha haptoglobin locus is on the long arm of chromosome 16, where its exact cytogenetic location is 16q22.2. A major function of haptoglobin is to bind hemoglobin (Hb) to form a stable Hp-Hb complex and thereby prevent Hb-induced oxidative tissue damage. Haptoglobin is an unusual secretory protein in that it is proteolytically processed in the endoplasmic reticulum and not in the Golgi. The human haptoglobin HP*2 allele contains a 1.7-kb intragenic duplication that arose after a unique nonhomologous recombination between the prototype HP*1 alleles.

Gene Full Name: haptoglobin

Sequence Similarities: Belongs to the peptidase S1 family.

Gene ID: 3240

UniProt: P00738

Pathways: Transition Metal Ion Homeostasis