HSPB8 antibody (AA 1-196) (Fluoro488)

Catalog No. ABIN7996189

The Mouse Monoclonal anti-HSPB8 antibody is suitable to detect HSPB8 in samples from Human and Rat. It has been validated for FACS.

Quick Overview for HSPB8 antibody (AA 1-196) (Fluoro488) (ABIN7996189)

Target: HSPB8 (Heat Shock 22kDa Protein 8 (HSPB8))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This HSPB8 antibody is conjugated to Fluoro488

Application: Flow Cytometry (FACS)

Clone: 7D8

Product Details anti-HSPB8 Antibody (Fluoro488)

Binding Specificity: AA 1-196

Purpose: Anti-HSPB8/Hsp22 Antibody (monoclonal, 7D8) Fluoro488 Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Predicted Reactivity: Human HSPB8,Hsp22 shares 94.4%,95.4% amino acid (aa) sequence identity with mouse,rat HSPB8,Hsp22,respectively.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human HSPB8/Hsp22 recombinant protein (Position: M1-T196). Human HSPB8/Hsp22 shares 94.4% and 95.4% amino acid (aa) sequence identity with mouse and rat HSPB8/Hsp22, respectively.

Isotype: IgG2b

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for HSPB8

Target: HSPB8 (Heat Shock 22kDa Protein 8 (HSPB8))

Alternative Name: HSPB8

Background:

Background: Heat shock protein beta-8 is a protein that in humans is encoded by the HSPB8 gene. The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.

Gene Full Name: heat shock protein family B (small) member 8

Gene ID: 26353

UniProt: Q9UJY1