HFE antibody (AA 112-227) (Cy3)

Catalog No. ABIN7996870

The Rabbit Polyclonal anti-HFE antibody is suitable to detect HFE in samples from Mouse and Rat. It has been validated for FACS.

Quick Overview for HFE antibody (AA 112-227) (Cy3) (ABIN7996870)

Target: HFE (Hemochromatosis (HFE))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HFE antibody is conjugated to Cy3

Application: Flow Cytometry (FACS)

Product Details anti-HFE Antibody (Cy3)

Binding Specificity: AA 112-227

Purpose: Anti-Hfe Antibody Cy3 Conjugated

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived mouse Hfe recombinant protein (Position: N112-H227).

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, 1-3 μg/1x10⁶ cells

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for HFE

Target: HFE (Hemochromatosis (HFE))

Alternative Name: Hfe

Background:

Background: Human homeostatic iron regulator protein, also known as the HFE protein (High FE2+), is a protein which in humans is encoded by the HFE gene. Enables transferrin receptor binding activity. Involved in positive regulation of gene expression. Acts upstream of or within hormone biosynthetic process and multicellular organismal iron ion homeostasis. Part of HFE-transferrin receptor complex. Is expressed in brain, choroid invagination, diencephalon roof plate, medulla oblongata part of 4th ventricle choroid plexus, and metencephalon part of 4th ventricle choroid plexus. Used to study hemochromatosis type 1. Human ortholog(s) of this gene implicated in several diseases, including acute porphyria (multiple), arthritis (multiple), bone marrow cancer (multiple), hemochromatosis (multiple), and liver disease (multiple). Orthologous to human HFE (homeostatic iron regulator).

Gene Full Name: homeostatic iron regulator

Gene ID: 15216

UniProt: P70387

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process