HPSE antibody (Middle Region) (PE)

Catalog No. ABIN7997020

The Rabbit Polyclonal anti-HPSE antibody is suitable to detect HPSE in samples from Human and Rat. It has been validated for FACS.

Quick Overview for HPSE antibody (Middle Region) (PE) (ABIN7997020)

Target: HPSE (Heparanase (HPSE))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HPSE antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Product Details anti-HPSE Antibody (PE)

Binding Specificity: Middle Region

Purpose: Anti-Heparanase 1/HPSE Antibody PE Conjugated

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the related mouse,rat sequences by eight amino acids.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human Heparanase 1, different from the related mouse and rat sequences by eight amino acids.

Isotype: IgG

Application Details

Application Notes: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Expiry Date: 12 months

Target Details for HPSE

Target: HPSE (Heparanase (HPSE))

Alternative Name: HPSE

Background:

Background: Heparanase, also known as HPSE, is an enzyme that acts both at the cell-surface and within the extracellular matrix to degrade polymeric heparan sulfate molecules into shorter chain length oligosaccharides. Heparanase is an endo-beta-D-glucuronidase capable of cleaving heparan sulfate and has been implicated in inflammation and tumor angiogenesis and metastasis. The successful penetration of the endothelial cell layer that lines the interior surface of blood vessels is an important process in the formation of blood borne tumour metastases. Heparan sulfate proteoglycans are major constituents of this layer and it has been shown that increased metastatic potential corresponds with increased heparanase activity for a number of cell lines.

Gene Full Name: heparanase

Sequence Similarities: Belongs to the cyclin family. Cyclin AB subfamily.

Gene ID: 10855

UniProt: Q9Y251

Pathways: Glycosaminoglycan Metabolic Process